QB payroll error 40001 in QuickBooks can be a major pain in the neck for users who are trying to process financial data. Basically, it prevents you from getting your work done and can cause all sorts of frustration, in particular when trying to activate direct deposit. For example, let's say you're trying to update payroll account info, but error 40001 pops up and stops you in your tracks. This can be super annoying and can make you anxious, especially if the work was urgent and requires to be done soon. It's not fun at all. So, yes, QuickBooks 40001 error is tough to deal with and it can really put a damper on your day.